Blast from the Past - Dr. Mario manga gives a wacky backstory to the puzzle game

The following info comes from the second entry in the Kodansha Media “KC Mario” series, called “Dr. Mario”

- Bowser cultivates the viruses in an attempt to conquer The Mushroom Kingdom
- once infected, the people of The Mushroom Kingdom laugh uncontrollably and cant’t stop
- Mario studies potential cures with the help of Princess Peach and Daisy
- the trio uses the Sky Pop to rain down capsules over the kingdom to save the day
- one virus escapes and infects Luigi
- Mario shrinks down in the Marine Pop to try and save him
- Bowser somehow also gets into Luigi’s body and Mario battles the viruses to save Luigi’s lif

from GoNintendo